A) Chemical structure of γ‐cyclodextrin (γ‐CD) and crosslinked CD‐MOF (CDF), and schematic diagram of RCLD. One unit of CDF is represented by the (γ‐CD)6 cube, while the (γ‐CD)6 units are connected to form 3D CDF nanocrystals. B) Schematic illustration of the role of RCLD in targeting lung cancer and inhibiting tumor cells.

Fig.2 Synthesis and characterization of RGD‐CDF‐LMWH.

该研究由上海药物所何亚平博士等完成，英国Bradford大学Laurence H. Patterson教授、上海药物所伍丽博士共同研讨和指导。该研究获中国科学院战略性先导科技专项个性化药物递送关键技术（XDA12050307）、国家重点研发计划重大疾病治疗药物制剂质量研究评价技术联合研究（2020YFE0201700）、重大新药创制（2018ZX09721002-009）和基金委面上项目（81773645）的资助。