在钯催化下通过导向基团（如吡啶和嘧啶）进行C-H位乙酰氧基化得反应.1,6

催化循环

反应实例

苯醌在反应中起到关键的促进作用。

在钯催化的C-H键官能团化得过程中导向基团的作用非常显著。

参考文献

1. Dick, A. R.; Hull, K. L.; Sanford, M. S. J. Am. Chem. Soc. 2004, 126, 2300–2301.Melanie S. Sanford was born in New Bedford, MA, in 1975. She received a B.S. and M.S. in chemistry from Yale University in 1996 before obtaining her Ph.D. at California Institute of Technology with Professor Robert Grubbs in 2001. She then completed postdoctoral studies at Princeton University working with Professor John Groves. In 2003, she joined the faculty of the University of Michigan where she is currently the Moses Gomberg Collegiate Professor of Chemistry as well as Arthur F. Thurnau Professor of Chemistry. Her research program focuses on the development of new catalysts and catalytic transformations for applications in the synthesis of useful organic molecules.

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编译自：J.J. Li, Name Reactions: A Collection of Detailed Mechanisms and Synthetic Applications,  Sanford reaction，page 115-116.